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dc.contributor.authorBhutani, Vinod K.
dc.contributor.authorZipursky, Alvin
dc.contributor.authorBlencowe, Hannah
dc.contributor.authorKhanna, Rajesh
dc.contributor.authorSgro, Michael
dc.contributor.authorEbbesen, Finn
dc.contributor.authorBell, Jennifer
dc.contributor.authorMori, Rintaro
dc.contributor.authorSlusher, Tina M.
dc.contributor.authorFahmy, Nahed
dc.contributor.authorPaul, Vinod K.
dc.contributor.authorDu, Lizhong
dc.contributor.authorOkolo, Angela A.
dc.contributor.authorAlmeida, Maria-Fernanda de [UNIFESP]
dc.contributor.authorOlusanya, Bolajoko O.
dc.contributor.authorKumar, Praveen
dc.contributor.authorCousens, Simon
dc.contributor.authorLawn, Joy E.
dc.identifier.citationPediatric Research. New York: Nature Publishing Group, v. 74, p. 86-100, 2013.
dc.description.abstractBACKGROUND: Rhesus (Rh) disease and extreme hyperbilirubinemia (EHB) result in neonatal mortality and long-term neurodevelopmental impairment, yet there are no estimates of their burden.METHODS: Systematic reviews and meta-analyses were undertaken of national prevalence, mortality, and kernicterus due to Rh disease and EHB. We applied a compartmental model to estimate neonatal survivors and impairment cases for 2010.RESULTS: Twenty-four million (18% of 134 million live births >= 32wk gestational age from 184 countries; uncertainty range: 23-26 million) were at risk for neonatal hyperbilirubinemia-related adverse outcomes. of these, 480,700(0.36%) had either Rh disease (373,300; uncertainty range: 271,800-477,500) or developed EHB from other causes (107,400; uncertainty range: 57,000-131,000), with a 24% risk for death (114,100; uncertainty range: 59,700-172,000), 13% for kernicterus (75,400), and 11% for stillbirths. Three-quarters of mortality occurred in sub-Saharan Africa and South Asia. Kernicterus with Rh disease ranged from 38, 28, 28, and 25/100,000 live births for Eastern Europe/Central Asian, sub-Saharan African, South Asian, and Latin American regions, respectively. More than 83% of survivors with kernicterus had one or more impairments.CONCLUSION: Failure to prevent Rh sensitization and manage neonatal hyperbilirubinemia results in 114,100 avoidable neonatal deaths and many children grow up with disabilities. Proven solutions remain underused, especially in low-income countries.en
dc.description.sponsorshipMarch of Dimes Prematurity Research Center at Stanford University School of Medicine
dc.description.sponsorshipBill and Melinda Gates Foundation
dc.publisherNature Publishing Group
dc.relation.ispartofPediatric Research
dc.rightsAcesso aberto
dc.titleNeonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levelsen
dc.contributor.institutionHosp Sick Children
dc.contributor.institutionStanford Univ
dc.contributor.institutionLondon Sch Hyg & Trop Med
dc.contributor.institutionSaving Newborn Lives Save Children
dc.contributor.institutionSt Michaels Hosp
dc.contributor.institutionAalborg Univ Hosp
dc.contributor.institutionNatl Ctr Child Hlth & Dev
dc.contributor.institutionUniv Minnesota
dc.contributor.institutionKasr Al Aini Univ
dc.contributor.institutionAll India Inst Med Sci
dc.contributor.institutionZhejiang Univ
dc.contributor.institutionNigerian Soc Neonatal Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Hlth Start Initiat
dc.contributor.institutionPost Grad Inst Med Educ & Res
dc.description.affiliationHosp Sick Children, Programme Global Paediat Res, Toronto, ON M5G 1X8, Canada
dc.description.affiliationStanford Univ, Dept Pediat, Div Neonatal & Dev Med, Sch Med,Lucile Packard Childrens Hosp, Stanford, CA 94305 USA
dc.description.affiliationLondon Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1, England
dc.description.affiliationSaving Newborn Lives Save Children, New Delhi, India
dc.description.affiliationSt Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada
dc.description.affiliationSt Michaels Hosp, Dept Paediat, Toronto, ON M5B 1W8, Canada
dc.description.affiliationAalborg Univ Hosp, Dept Pediat, Aalborg, Denmark
dc.description.affiliationNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Tokyo, Japan
dc.description.affiliationUniv Minnesota, Ctr Global Pediat, Minneapolis, MN USA
dc.description.affiliationKasr Al Aini Univ, El Mounira Childrens Hosp, Dept Pediat, Cairo, Egypt
dc.description.affiliationAll India Inst Med Sci, WHO Collaborating Ctr Training & Res Newborn Care, New Delhi, India
dc.description.affiliationZhejiang Univ, Sch Med, Childrens Hosp, Hangzhou 310003, Zhejiang, Peoples R China
dc.description.affiliationNigerian Soc Neonatal Med, Lagos, Nigeria
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.affiliationCtr Hlth Start Initiat, Lagos, Nigeria
dc.description.affiliationPost Grad Inst Med Educ & Res, Chandigarh, India
dc.description.affiliationLondon Sch Hyg & Trop Med, Ctr Maternal Reprod & Child Hlth, London WC1, England
dc.description.affiliationSaving Newborn Lives Save Children, Washington, DC USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
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