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Title: Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process
Authors: Gibaile Soares, Rubens Murilo
Dias, Alyria Teixeira
Ribeiro de Castro, Sandra Bertelli
Souza Alves, Caio Cesar
Evangelista, Marcilene Gomes
Da Silva, Luan Cristian
Farias, Rogerio Estevam
Marques Nogueira Castanon, Maria Christina
Juliano, Maria Aparecida [UNIFESP]
Ferreira, Ana Paula
Univ Fed Juiz de Fora
Universidade Federal de São Paulo (UNIFESP)
Keywords: Experimental autoimmune encephalomyelitis
multiple sclerosis
optic nerve
Issue Date: 1-Nov-2013
Publisher: Informa Healthcare
Citation: Autoimmunity. London: Informa Healthcare, v. 46, n. 7, p. 480-485, 2013.
Abstract: Optical neuritis (ON) is characterized by inflammation of the optic nerve, and is one of the first clinical signs of multiple sclerosis (MS). Experimental autoimmune encephalomyelitis (EAE) is the animal model used to study MS and ON. the present study evaluated the induction, development and progression of ON using an EAE model induced by 100 mu g or 300 mu g of MOG(35-55). An EAE model was induced in C57BL/6 mice by tail base injection of 100 mu g or 300 mu g of MOG(35-55) in complete Freund's adjuvant, supplemented with Mycobacterium tuberculosis. On the day of injection and 48 h later, animals received intraperitoneally 300 ng of pertussis toxin. On days 7, 10, 14, 21 and 58 the optic nerve was dissected for histological analysis, production of CCL5 and immunohistochemical detection of CD4 and CD8. the histological changes observed in the optic nerves consisted of inflammatory cell infiltrates showing varying degrees of ON in the two groups. the onset of ON in the 300 mu g of MOG(35-55) group was coincident with higher production of CCL5, on day 10 after induction. However, the 100 mu g MOG(35-55) group showed more intense inflammatory infiltrate on day 14 after induction, with higher amounts of CD4 and CD8, reaching an excessive demyelination process on days 21 and 58 after induction. the results suggest that two different concentrations of MOG(35-55) lead to different forms of evolution of optic neuritis.
ISSN: 0891-6934
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