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Title: Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation
Authors: Dierselhuis, M. P.
Spierings, E.
Drabbels, J.
Hendriks, M.
Alaez, C.
Alberu, J.
Alvarez, M. B.
Burlingham, W.
Campos, E. [UNIFESP]
Christiaans, M.
Claas, F.
Fasano, M. E.
Gerbase-DeLima, M.
Gervais, T.
Gorodezky, C.
Larriba, J.
Lardy, N. M.
Latinne, D.
Morales-Buenrostro, L-E
Moreno, M. J.
Oguz, F.
Opelz, G.
Sergeant, R.
Tambutti, M.
Teper, S.
Tilanus, M.
Turkmen, A.
Warrens, A. N.
Weimar, W.
Goulmy, E.
Leiden Univ
Univ Med Ctr Utrecht
Inst Diagnost & Referencia Epidemiol
Inst Nacl Ciencias Med & Nutr Salvador Zubiran
Ctr Inmunol Genet & Mol
Univ Wisconsin
Universidade Federal de São Paulo (UNIFESP)
Associacao Fundo Incent Pesquisa
Maastricht Univ
Immunol Trapianti Genet
Catholic Univ Louvain
Hosp Italiano Buenos Aires
Sanquin Diagnost Serv
CEMIC Ctr Educ Med & Invest Clin Norberto Quirno
Istanbul Univ
Heidelberg Univ
Imperial Coll Healthcare NHS Trust
Erasmus MC
Keywords: human leukocyte antigen-identical
minor H antigen
non human leukocyte antigen
renal transplantation
Issue Date: 1-Nov-2013
Publisher: Wiley-Blackwell
Citation: Tissue Antigens. Hoboken: Wiley-Blackwell, v. 82, n. 5, p. 312-316, 2013.
Abstract: Studies of the effect of minor H antigen mismatching on the outcome of renal transplantation are scarce and concern mainly single center studies. the International Histocompatibility and Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large studies. in collaboration with 16 laboratories of the IHIW, the role of 15 autosomal, 10 Y-chromosome encoded minor H antigens and 3 CD31 polymorphisms, was investigated in relation to the incidence of renal graft rejection and graft loss in 444 human leukocyte antigens (HLA)-identical sibling renal transplantations. Recipient and donor DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, C19Orf48, LB-ECGF-1, CTSH, LRH-1, LB-ADIR and HY. the correlation between minor H antigen mismatch and the primary outcome graft rejection or graft loss was statistically analyzed. the incidence of rejection was very low and no correlation was observed between one or more minor H antigen mismatch(es) and a rejection episode (n=36), of which only eight resulted in graft loss. in summary, in our study cohort of 444 renal transplants, mismatching for neither autosomal nor HY minor H antigens correlate with rejection episodes or with graft loss.
ISSN: 0001-2815
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