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Title: Atopic dermatitis and vitamin D: facts and controversies
Authors: Mesquita, Kleyton de Carvalho
Igreja, Ana Carolina de Souza Machado
Costa, Izelda Maria Carvalho [UNIFESP]
Universidade de Brasília (UnB)
Fed Dist Hlth State Dept SES DF
Universidade Federal de São Paulo (UNIFESP)
Keywords: Defensins
Vitamin D
Vitamin D Deficiency
Issue Date: 1-Nov-2013
Publisher: Soc Brasileira Dermatologia
Citation: Anais Brasileiros de Dermatologia. Rio de Janeiro Rj: Soc Brasileira Dermatologia, v. 88, n. 6, p. 945-953, 2013.
Abstract: Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.
ISSN: 0365-0596
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