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Title: Strategies to prevent hydrolytic degradation of the hybrid layer-A review
Authors: Tjaderhane, Leo
Nascimento, Fabio D.
Breschi, Lorenzo
Mazzoni, Annalisa
Tersariol, Ivarne L. S. [UNIFESP]
Geraldeli, Saulo
Tezvergil-Mutluay, Arzu
Carrilho, Marcela
Carvalho, Ricardo M.
Tay, Franklin R.
Pashley, David H.
Univ Oulu
Univ Turku
NordicInst Dent Mat NIOM
Biomat Res Grp UNIBAN
Univ Trieste
Univ Mogi das Cruzes
Universidade Federal de São Paulo (UNIFESP)
Univ Florida
Univ Western Ontario
Univ British Columbia
Med Coll Georgia
Keywords: Dentin bonding
Matrix metalloproteinases
Cysteine cathepsins
Enzyme inhibition
Hybrid layer
Issue Date: 1-Oct-2013
Publisher: Elsevier B.V.
Citation: Dental Materials. Oxford: Elsevier B.V., v. 29, n. 10, p. 999-1011, 2013.
Abstract: Objective. Endogenous dentin collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, are responsible for the time-dependent hydrolysis of collagen matrix of hybrid layers. As collagen matrix integrity is essential for the preservation of long-term dentin bond strength, inhibition of endogenous dentin proteases is necessary for durable resin-bonded restorations.Methods. Several tentative approaches to prevent enzyme function have been proposed. Some of them have already demonstrated clinical efficacy, while others need to be researched further before clinical protocols can be proposed. This review will examine both the principles and outcomes of techniques to prevent collagen hydrolysis in dentin-resin interfaces.Results. Chlorhexidine, a general inhibitor of MMPs and cysteine cathepsins, is the most tested method. in general, these experiments have shown that enzyme inhibition is a promising approach to improve hybrid layer preservation and bond strength durability. Other enzyme inhibitors, e. g. enzyme-inhibiting monomers, may be considered promising alternatives that would allow more simple clinical application than chlorhexidine. Crosslinking collagen and/or dentin matrix-bound enzymes could render hybrid layer organic matrices resistant to degradation. Alternatively, complete removal of water from the hybrid layer with ethanol wet bonding or biomimetic remineralization should eliminate hydrolysis of both collagen and resin components.Significance. Understanding the function of the enzymes responsible for the hydrolysis of hybrid layer collagen has prompted several innovative approaches to retain hybrid layer integrity and strong dentin bonding. the ultimate goal, prevention of collagen matrix degradation with clinically applicable techniques and commercially available materials may be achievable in several ways. (C) 2013 Academy of Dental Materials. Published by Elsevier B.V. All rights reserved.
ISSN: 0109-5641
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