Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/36785
Title: Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Authors: Borges, Fernanda Teixeira [UNIFESP]
Reis, L. A. [UNIFESP]
Schor, Nestor [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Univ Cruzeiro Sul
Keywords: Extracellular vesicles
Cell biology
Kidney diseases
Diagnosis
Treatment
Issue Date: 1-Oct-2013
Publisher: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 10, p. 824-830, 2013.
Abstract: Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40- 100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. the therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of wellcharacterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.
URI: http://repositorio.unifesp.br/handle/11600/36785
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/1414-431X20132964
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