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|Title:||BONE MARROW STEM CELLS in FACIAL NERVE REGENERATION FROM ISOLATED STUMPS|
Bento, Ricardo F.
Costa, Heloisa J. Z. R.
Ovando, Patricia C. [UNIFESP]
Da-Silva, Cira F.
Zanatta, Daniela B.
Strauss, Bryan E.
Haddad, Luciana A.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
|Citation:||Muscle & Nerve. Hoboken: Wiley-Blackwell, v. 48, n. 3, p. 423-429, 2013.|
|Abstract:||IntroductionSevere lesions in the facial nerve may have extensive axonal loss and leave isolated stumps that impose technical difficulties for nerve grafting. Methods: We evaluated bone marrow stem cells (BMSC) in a silicone conduit for rat facial nerve regeneration from isolated stumps. Group A utilized empty silicone tubes; in groups B-D, the tube was filled with acellular gel; and, in groups C and D, undifferentiated BMSC (uBMSC) or Schwann-like cells differentiated from BMSC (dBMSC) were added, respectively. Compound muscle action potentials (CMAPs) were measured, and histology was evaluated. Results: Groups C and D had the highest CMAP amplitudes. Group C had shorter CMAP durations than groups A, B, and D. Distal axonal number and density were increased in group C compared with groups A and B. Conclusions: Regeneration of the facial nerve was improved by both uBMSC and dBMSC in rats, yet uBMSC was associated with superior functional results.|
|Appears in Collections:||Em verificação - Geral|
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