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Title: Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects
Authors: Saddi-Rosa, Pedro [UNIFESP]
Oliveira, Carolina Soares [UNIFESP]
Crispim, Felipe [UNIFESP]
Giuffrida, Fernando de Mello Almada [UNIFESP]
Lima, Valter Correia de [UNIFESP]
Vieira, Jose Gilberto [UNIFESP]
Doria, Alessandro
Velho, Gilberto
Reis, Andre Fernandes [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Joslin Diabet Ctr
Univ Paris 07
Keywords: NAMPT
Coronary artery disease
Type 2 diabetes
Issue Date: 22-Aug-2013
Publisher: Biomed Central Ltd
Citation: Cardiovascular Diabetology. London: Biomed Central Ltd, v. 12, 7 p., 2013.
Abstract: Background: Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor and a potential regulatory factor in inflammatory and immune processes. Associations of circulating NAMPT levels with cardiovascular disease (CVD) and insulin resistance have been reported. We investigated association of circulating NAMPT levels and the rs9770242 NAMPT gene polymorphism with coronary artery disease (CAD).Methods: We studied 594 Brazilian subjects undergoing a coronary angiography (49% of whom had type 2 diabetes). CAD, defined as stenosis greater than 50% in one major coronary vessel or branch, was observed in 68% of subjects. Genetic studies were also performed in 858 North-American Non-Hispanic White subjects with type 2 diabetes (49% with CAD).Results: We observed an interaction between glycemic and CAD status on the comparison of NAMPT levels by CAD status. NAMPT levels were higher in type 2 diabetic patients with CAD as compared to those without CAD: 5.27 +/- 2.93 ng/ml vs. 4.43 +/- 2.94 ng/ml, p = 0.006 (mean +/- SD). NAMPT levels were not significantly different in non-diabetic subjects with or without CAD. the T-allele of rs9770242 was associated with CAD in the Brazilian cohort (OR 1.46, 95% CI 1.06 - 2.01, p = 0.02) while no association was observed in the North-American cohort.Conclusions: Our data suggest that circulating NAMPT levels are associated with CAD in type 2 diabetic patients. NAMPT rs9770242 polymorphism may be associated with CAD in some populations.
ISSN: 1475-2840
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