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Title: Factors Influencing Health Related Quality of Life in Cancer Patients with Bone Metastases
Authors: Wong, Erin
Chow, Edward
Zhang, Liying
Bedard, Gillian
Lam, Kinsey
Fairchild, Alysa
Vassiliou, Vassilios
El-Din, Mohamed A. Alm
Jesus-Garcia, Reynaldo [UNIFESP]
Kumar, Aswin
Forges, Fabien
Tseng, Ling-Ming
Hou, Ming-Feng
Chie, Wei-Chu
Bottomley, Andrew
Univ Toronto
Cross Canc Inst
Bank Cyprus Oncol Ctr
Tanta Univ Hosp
Universidade Federal de São Paulo (UNIFESP)
Reg Canc Ctr
Lucien Neuwirth Canc Inst
Natl Yang Ming Univ
Kaohsiung Med Univ Hosp
Natl Taiwan Univ
European Org Res Treatment Canc
Issue Date: 1-Aug-2013
Publisher: Mary Ann Liebert, Inc
Citation: Journal of Palliative Medicine. New Rochelle: Mary Ann Liebert, Inc, v. 16, n. 8, p. 915-921, 2013.
Abstract: Objective: Health related quality of life (HRQOL) is a multidimensional concept that is especially important for cancer patients with bone metastases, as maintaining and improving HRQOL is often the main focus of treatment. This study aims to determine factors that may influence HRQOL, which may in turn influence treatment and care of patients.Methods: Patients (n = 396) completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) Bone Metastases module (BM22) at baseline. the EORTC QLQ-BM22 consists of four scales: painful site (PS), pain characteristics (PC), functional interference (FI), and psychosocial aspect (PA) scales. EORTC QLQ-BM22 data, together with sociodemographic and medical factors were analyzed by univariate analysis of variance (ANOVA). Items of significance were determined through backward selection, which were then put through multivariate analysis to determine further significance.Results: Through ANOVA analysis, KPS > 80 and breast primary histology were predictive of better HRQOL in the PS scale, while KPS > 80, female gender, and breast primary histology were predictive of better HRQOL in the PC and FI scales. KPS > 80 and prostate primary histology were predictive of better HRQOL in the PA scale. KPS > 80 and primary cancer site were confirmed as significant predictive factors in multivariate analysis.Recommendations: This study identified baseline factors of gender, performance status, and primary histology as determinants of HRQOL in patients with bone metastases. Further study focusing on current treatment (chemotherapy, bisphosphonates, and radiotherapy) and spiritual well-being may identify additional factors affecting HRQOL. Understanding the influence of these factors will allow health care professionals to provide more effective palliative care.
ISSN: 1096-6218
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