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Title: Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
Authors: McNeill, Alisdair
Wu, Ruey-Meei
Tzen, Kai-Yuan
Aguiar, Patricia C.
Arbelo, Jose M.
Barone, Paolo
Bhatia, Kailash
Barsottini, Orlando [UNIFESP]
Bonifati, Vincenzo
Bostantjopoulou, Sevasti
Bressan, Rodrigo
Cossu, Giovanni
Cortelli, Pietro
Felicio, Andre
Ferraz, Henrique B. [UNIFESP]
Herrera, Joanna
Houlden, Henry
Hoexter, Marcelo
Isla, Concepcion
Lees, Andrew
Lorenzo-Betancor, Oswaldo
Mencacci, Niccolo E.
Pastor, Pau
Pappata, Sabina
Pellecchia, Maria Teresa
Silveria-Moriyama, Laura
Varrone, Andrea
Foltynie, Tom
Schapira, Anthony H. V.
Birmingham Womens Hosp
Natl Taiwan Univ Hosp
Hosp Israelita Albert Einstein
Hosp Univ Insular Gran Canaria
Univ Salerno
Universidade Federal de São Paulo (UNIFESP)
Erasmus MC
Aristotle Univ Thessaloniki
Gen Hosp S Michele AOB G Brotzu
Univ Bologna
UCL Inst Neurol
Univ Navarra
Karolinska Inst
Issue Date: 23-Jul-2013
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 8, n. 7, 7 p., 2013.
Abstract: Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. the right: left asymmetry index and striatal asymmetry index was calculated.Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). the asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions: the asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
ISSN: 1932-6203
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