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dc.contributor.authorKichuk, Stephen A.
dc.contributor.authorTorres, Albina R.
dc.contributor.authorFontenelle, Leonardo F.
dc.contributor.authorRosario, Maria Conceicao [UNIFESP]
dc.contributor.authorShavitt, Roseli G.
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorPittenger, Christopher
dc.contributor.authorBloch, Michael H.
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 44, p. 233-239, 2013.
dc.description.abstractMeta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. for age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. for analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course. (C) 2013 Published by Elsevier Inc.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNational Institute of Mental Health
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipAPIRE/Eli Lilly Psychiatric Research Fellowship
dc.description.sponsorshipAACAP/Eli Lilly Junior Investigator Award
dc.description.sponsorshipTrichotillomania Learning Center
dc.description.sponsorshipDoris Duke Charitable Foundation
dc.description.sponsorshipNational Center for Research Resources, a component of the National Institutes of Health
dc.description.sponsorshipNIH roadmap for Medical Research
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsAcesso restrito
dc.titleSymptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorderen
dc.contributor.institutionYale Univ
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationYale Univ, Dept Psychiat, New Haven, CT 06520 USA
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Psychiat, Anxiety & Depress Res Program, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, São Paulo, SP, Brazil
dc.description.affiliationYale Univ, Dept Psychol, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Ctr Child Study, New Haven, CT 06520 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2005/55628-8
dc.description.sponsorshipIDCNPq: 573974/2008-0
dc.description.sponsorshipIDNational Institutes of Health: K23MH091240
dc.description.sponsorshipIDNational Institutes of Health: K08MH081190
dc.description.sponsorshipIDNational Center for Research Resources, a component of the National Institutes of Health: UL1 RR024139
dc.description.sourceWeb of Science
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