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Title: Nutritional status and metabolic disorders in HIV-exposed uninfected prepubertal children
Authors: Claudio, Cristiane Chiantelli [UNIFESP]
Patin, Rose Vega [UNIFESP]
Palchetti, Cecilia Zanin [UNIFESP]
Machado, Daisy Maria [UNIFESP]
Menezes Succi, Regina Celia de [UNIFESP]
Oliveira, Fernanda Luisa Ceragioli [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Dyslipidemia
Issue Date: 1-Jul-2013
Publisher: Elsevier B.V.
Citation: Nutrition. New York: Elsevier B.V., v. 29, n. 7-8, p. 1020-1023, 2013.
Abstract: Objective: the objective of the study was to assess the nutritional status and metabolic alterations in HIV-exposed uninfected (HIVe) children compared with HIV-unexposed (HIVn) children.Methods: A cross-sectional study was carried out with 76 children distributed into two groups: HIVe (n = 31) and HIVn (n = 45). Biochemical data (hematologic test, lipid profile, insulin resistance, hepatic profile, and C-reactive protein) were evaluated. Anthropometric parameters and body composition analyses were performed.Results: the groups were similar regarding body mass index-for-age z-scores (P = 0.297) and height-for-age z-scores (P = 0.666). HIVe had a higher dyslipidemia prevalence (38.7% versus 11.1%; P = 0.010), altered total cholesterol (TC) values (19.4% versus 2.2%; P = 0.016) higher LDL-C mean levels (97.8 mg/dl versus 86 mg/dl; P = 0.028), borderline low-density lipoprotein cholesterol (LDL-C) (40% versus 14%; P = 0.011) and TC (41.9% versus 20%; P = 0.038) compared with HIVn.Conclusion: Despite the similar nutritional status between groups, our data clearly demonstrated a higher prevalence of dyslipidemia, altered TC, higher LDL-C levels and also LDL-C and TC borderline values in HIVe children. (C) 2013 Elsevier Inc. All rights reserved.
ISSN: 0899-9007
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