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Title: Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
Authors: Modabbernia, Amirhossein
Taslimi, Shervin
Brietzke, Elisa [UNIFESP]
Ashrafi, Mandana
Univ Tehran Med Sci
Universidade Federal de São Paulo (UNIFESP)
Keywords: Bipolar disorder
Issue Date: 1-Jul-2013
Publisher: Elsevier B.V.
Citation: Biological Psychiatry. New York: Elsevier B.V., v. 74, n. 1, p. 15-25, 2013.
Abstract: Background: We conducted a meta-analysis of studies comparing cytokine concentrations between patients with bipolar disorder (BD) and healthy control subjects (HCs).Methods: We searched ISI Web of Science, MEDLINE, BIOSIS Previews, Scopus, Current Contents Connect, and Biological Abstracts for relevant studies. Based on heterogeneity status, we used fixed-effect or restricted maximal likelihood model to perform meta-analysis.Results: Thirty studies with a total of 2599 participants (1351 BD and 1248 HCs) were eligible for the analysis. Concentrations of interleukin (IL)-4 (p = .008), IL-6 (p = .073), IL-10 (p = .013), soluble IL-2 receptor (sIL-2R; p < .001), sIL-6R (p = .021), tumor necrosis factor (TNF)-alpha (p = .010), soluble TNF receptor-1 (sTNFR1; p < .001), and IL-1 receptor antagonist (p value in mania <.001 and euthymia = .021) were significantly elevated in patients compared with HCs. Moreover, IL-1 beta (p = .059), and IL-6 (p = .073) tended to show higher values in patients. Levels of IL-2 (p = .156), interferon (INF)-gamma (p = .741), C-C motif ligand 2 (p = .624), and IL-8 (p = .952) did not significantly differ between patients and HCs. Subgroup analysis based on mitogen stimulation status partially or completely resolved heterogeneity for most of the cytokines. Concentrations of IL-2, IL-4, sIL-6R, and INF-gamma were unrelated to medication status. Phasic difference was present for TNF-alpha, sTNFR1, sIL-2R, IL-6, and IL-1RA, whereas it was absent for IL-4 and IL-10.Conclusions: This meta-analysis provides evidence for significant elevation of proinflammatory, anti-inflammatory, and regulatory cytokines in BD.
ISSN: 0006-3223
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