Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/36401
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dc.contributor.authorLopes, Marcio D. [UNIFESP]
dc.contributor.authorColugnati, Diego Basile [UNIFESP]
dc.contributor.authorLopes, Antonio C. [UNIFESP]
dc.contributor.authorScorza, Carla A. [UNIFESP]
dc.contributor.authorCavalheiro, Esper A. [UNIFESP]
dc.contributor.authorCysneiros, Roberta M.
dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.date.accessioned2016-01-24T14:31:51Z
dc.date.available2016-01-24T14:31:51Z
dc.date.issued2013-06-01
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2013.02.017
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 27, n. 3, p. 504-506, 2013.
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36401
dc.description.abstractSince cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. in agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. in conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent504-506
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsAcesso restrito
dc.subjectSUDEPen
dc.subjectEpilepsyen
dc.subjectHeart rateen
dc.subjectPilocarpineen
dc.subjectOmega-3 fatty acids (omega-3 FAs)en
dc.titleOmega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsyen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Dept Ciencias Fisiol, Goiania, Go, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Med, São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Med, São Paulo, Brazil
dc.identifier.doi10.1016/j.yebeh.2013.02.017
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000318615600014
Appears in Collections:Artigo

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