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Title: Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy
Authors: Lopes, Marcio D. [UNIFESP]
Colugnati, Diego Basile [UNIFESP]
Lopes, Antonio C. [UNIFESP]
Scorza, Carla A. [UNIFESP]
Cavalheiro, Esper A. [UNIFESP]
Cysneiros, Roberta M.
Scorza, Fulvio A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Univ Presbiteriana Mackenzie
Keywords: SUDEP
Heart rate
Omega-3 fatty acids (omega-3 FAs)
Issue Date: 1-Jun-2013
Publisher: Elsevier B.V.
Citation: Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 27, n. 3, p. 504-506, 2013.
Abstract: Since cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. in agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. in conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP. (C) 2013 Elsevier Inc. All rights reserved.
ISSN: 1525-5050
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