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Title: Incidence of toxoplasma retinochoroiditis in patients after using TNF-alpha blockers
Authors: Paula Rodrigues, Kelly Fernandes de [UNIFESP]
Faria e Arantes, Tiago Eugenio [UNIFESP]
Muccioli, Cristina [UNIFESP]
Andrade Neto, Joao Lins de [UNIFESP]
Pinheiro, Marcelo M. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Toxoplasma
Ankylosing spondylitis
TNF-alpha blockers
Prospective study with control group
Issue Date: 1-Jun-2013
Publisher: Elsevier B.V.
Citation: Parasitology International. Clare: Elsevier B.V., v. 62, n. 3, p. 272-275, 2013.
Abstract: TNE-alpha blockers are associated with reactivation of latent granulomatous infections and almost 6% of the world population has some chorioretinitis (CR) caused by Toxoplasma gondii. Thus, the blockade of TNF-alpha could reactivate a latent toxoplasmosis infection (LTxl). This study was conducted to evaluate the prevalence and incidence of chronic and active CR related to T. gondii in patients with ankylosing spondylitis (AS). A total of 74 eyes from 37 active AS outpatients starting TNF alpha blockers were compared with 35 AS patients, matched to age and sex, under conventional therapy in a prospective and controlled trial. All patients underwent serological tests for T. gondii, as well as periodic ophthalmologic examination during 12 months. Active CR was defined if a white, focal retinochoroidal lesion with overlying vitreous inflammation had been found. Retinochoroidal lesions with sharp edges, hyperpigmented borders and atrophic center were defined as CR scars. At baseline, no patient had active CR. From the 144 eyes examined, almost 6% had CR scars and only 2.1% had a typical toxoplasmic CR scar and all of them were negative for HLA-B27. During 12 months of follow-up, no recurrence or new CR were observed. AS patients using TNF-alpha blockers do not have a higher risk of acute or chronic CR caused by T. gondii. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
ISSN: 1383-5769
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