Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/36353
Title: Effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of atrial beta-adrenergic receptors
Authors: das Neves, Vander Jose
Tanno, Ana Paula
Cunha, Tatiana Sousa [UNIFESP]
Fernandes, Tiago
Guzzoni, Vinicius
Silva, Carlos Alberto da
Oliveira, Edilamar Menezes de
Costa Sampaio Moura, Maria Jose
Marcondes, Fernanda Klein
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Metodista Piracicaba
Keywords: Cardiac hypertrophy
Arterial blood pressure
Electrocardiography
Training
Anabolic steroids
Beta-adrenergic receptors
Issue Date: 30-May-2013
Publisher: Elsevier B.V.
Citation: Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 92, n. 20-21, p. 1029-1035, 2013.
Abstract: Aims: This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the beta(1)- and beta(2)-adrenergic receptors in the heart of rats.Main methods: Wistar rats were randomly divided into four groups and submitted to a 6-week treatment with nandrolone and/or resistance training. Cardiac hypertrophy was accessed by the ratio of heart weight to the final body weight. Blood pressure was determined by a computerized tail-cuff system. Electrocardiography analyses were performed. Western blotting was used to access the protein levels of the beta(1)- and beta(2)-adrenergic receptors in the right atrium and left ventricle.Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased systolic blood pressure depending on the treatment time. Resistance training decreased systolic, diastolic and mean arterial blood pressure, as well as induced resting bradycardia. Nandrolone prolonged the QTc interval for both trained and non-trained groups when they were compared to their respective vehicle-treated one. Nandrolone increased the expression of beta(1)- and beta(2)-adrenergic receptors in the right atrium for both trained and non-trained groups when they were compared to their respective vehicle-treated one.Significance: This study indicated that nandrolone, associated or not with resistance training increases blood pressure depending on the treatment time, induces prolongation of the QTc interval, and increases the expression of beta(1)- and beta(2)-adrenergic receptors in the cardiac right atrium, but not in the left ventricle. (c) 2013 Published by Elsevier Inc.
URI: http://repositorio.unifesp.br/handle/11600/36353
ISSN: 0024-3205
Other Identifiers: http://dx.doi.org/10.1016/j.lfs.2013.04.002
Appears in Collections:Em verificação - Geral

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