Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/36347
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dc.contributor.authorTeixeira de Souza, Carolina Rosal
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorCosta Sozinho, Eliana Kelly
dc.contributor.authorBorges, Barbara do Nascimento
dc.contributor.authorMontenegro, Raquel Carvalho
dc.contributor.authorCampos Ribeiro dos Santos, Andrea Kely
dc.contributor.authorBatista dos Santos, Sidney Emanuel
dc.contributor.authorRibeiro, Helem Ferreira
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.date.accessioned2016-01-24T14:31:46Z-
dc.date.available2016-01-24T14:31:46Z-
dc.date.issued2013-05-22
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0064420
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 8, n. 5, 9 p., 2013.
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36347-
dc.description.abstractOur study investigated the relationship between MYC alterations and clinicopathological features in gastric cancers. We evaluated the effect of MYC mRNA expression and its protein immunoreactivity, as well as copy number variation, promoter DNA methylation, and point mutations, in 125 gastric adenocarcinoma and 67 paried non-neoplastic tissues. We observed that 77% of the tumors presented MYC immunoreactivity which was significantly associated with increased mRNA expression (p < 0.05). These observations were associated with deeper tumor extension and the presence of metastasis (p < 0.05). MYC protein expression was also more frequently observed in intestinal-type than in diffuse-type tumors (p < 0.001). Additionally, MYC mRNA and protein expression were significantly associated with its copy number (p < 0.05). the gain of MYC copies was associated with late-onset, intestinal-type, advanced tumor stage, and the presence of distant metastasis (p < 0.05). A hypomethylated MYC promoter was detected in 86.4% of tumor samples. MYC hypomethylation was associated with diffuse-type, advanced tumor stage, deeper tumor extension, and the presence of lymph node metastasis (p < 0.05). Moreover, eighteen tumor samples presented at least one known mutation. the presence of MYC mutations was associated with diffuse-type tumor (p < 0.001). Our results showed that MYC deregulation was mainly associated with poor prognostic features and also reinforced the presence of different pathways involved in intestinal-type and diffuse-type gastric carcinogenesis. Thus, our findings suggest that MYC may be a useful marker for clinical stratification and prognosis.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent9
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleMYC Deregulation in Gastric Cancer and Its Clinicopathological Implicationsen
dc.typeArtigo
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66059 Belem, Para, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, São Paulo, Brazil
dc.description.affiliationFed Univ Para, Inst Ciencias Biol, Lab Genet Humana & Med, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Para, Nucleo Pesquisa Oncol, BR-66059 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, São Paulo, Brazil
dc.identifier.fileWOS000320362700146.pdf
dc.identifier.doi10.1371/journal.pone.0064420
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000320362700146
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