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Title: DNA damage, p53, Ki-67 and COX-2 expression in rat tongue cells exposed to nandrolone decanoate
Authors: Pozzi, Renan [UNIFESP]
Fernandes, Kelly Rossetti [UNIFESP]
Moura, Carolina Foot Gomes de [UNIFESP]
Mesquita Ferrari, Raquel Agnelli
Fernandes, Kristianne Porta Santos
Chaves, Marcelo Donizeti [UNIFESP]
Renno, Ana Claudia Muniz [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Nove Julho Univ
Keywords: COX-2
DNA damage
nandrolone decanoate p53
Issue Date: 1-May-2013
Publisher: Informa Healthcare
Citation: Toxicology Mechanisms and Methods. London: Informa Healthcare, v. 23, n. 4, p. 289-296, 2013.
Abstract: The objective of this article was to evaluate the impact potential of nandrolone decanoate on DNA damage, cellular regulatory proteins and cyclooxygenase (COX)-2 in oral mucosa cells of Wistar rats. A total of 40 rats were distributed into four groups. Two experimental groups were treated with nandrolone decanoate, at 5 mg/kg doses, subcutaneously, three times a week in two periods: 15 and 30 days. the remaining groups received only 0.9% saline subcutaneously, three times a week. To evaluate genetic damage, nandrolone decanoate at 15 mg/kg dose was exposed to 24 h. in the histopathological analysis, no remarkable morphological changes were observed in tongue tissue in all groups. Significant increase in immunoexpression of Ki-67, p53, COX-2 proteins was detected in the groups treated with nandrolone decanoate during 15 and 30 days, when compared to their respective controls. A positive correlation between immunoexpression of p53 and COX-2 protein was detected following nandrolone decanoate exposure. DNA damage was induced by nandrolone decanoate in oral mucosa cells at 15 mg/kg dose. Our results suggest that nandrolone decanoate was able to alter the expression of cell cycle-related proteins, as well as to induce genetic damage and COX-2 immunoexpression in tongue cells of Wistar rats.
ISSN: 1537-6516
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