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|Title:||The Morquio A Clinical Assessment Program: Baseline results illustrating progressive, multisystemic clinical impairments in Morquio A subjects|
Mengel, Karl Eugen
Burton, Barbara K.
Hendriksz, Christian J.
Martins, Ana Maria [UNIFESP]
Childrens Hosp & Res Ctr Oakland
MC Univ Mainz
Univ Fed Rio Grande do Sul
Hop Necker Enfants Malad
Mackay Mem Hosp
Mackay Med Coll
Az Osped S Gerardo
Hop Femme Mere Enfant
Ann & Robert H Lurie Childrens Hosp
Birmingham Childrens Hosp NHS Fdn Trust
Universidade Federal de São Paulo (UNIFESP)
Hosp Ninos Cordoba
Great Ormond St Hosp Sick Children
Lysosomal storage disorder
|Citation:||Molecular Genetics and Metabolism. San Diego: Academic Press Inc Elsevier Science, v. 109, n. 1, p. 54-61, 2013.|
|Abstract:||Objectives: the objectives of this study are to quantify endurance and respiratory function and better characterize spectrum of symptoms and biochemical abnormalities in mucopolysaccharidosis IVA subjects.Methods: MorCAP was a multicenter, multinational, cross sectional study amended to be longitudinal in 2011. Each study visit required collection of medical history, clinical assessments, and keratan sulfate (KS) levels.Results: Data from the first visit of 325 subjects (53% female) were available. Mean age was 14.5 years. Mean +/- SD height z-scores were -5.6 +/- 3.1 as determined by the CDC growth charts. Mean +/- SD from the 6-minute-walk-test was 212.6 +/- 1522 m, revealing limitations in functional endurance testing, and 30.0 +/- 24.0 stairs/min for the 3-minute-stair-climb test. Respiratory function showed limitations comparable to MPS VI patients; mean +/- SD was 1.2 +/- 0.9 1 based on forced vital capacity and 34.8 +/- 25.5 l/min based on maximum voluntary ventilation. Mean urinary keratan sulfate (uKS) was elevated for all ages, and negatively correlated with age. Higher uKS correlated with greater clinical impairment based on height z-scores, endurance and respiratory function tests. the MPS Health Assessment Questionnaire reveals impairments in mobility and activities of daily living in comparison to an age-matched control population.Conclusions: MPS IVA is a multisystem disorder with a continuum of clinical presentation. All affected individuals experience significant functional limitations and reduced quality of life. Older patients have more severe exercise and respiratory capacity limitations, and more frequent cardiac pathology illustrating the progressive nature of disease. (C) 2013 Elsevier Inc. All rights reserved.|
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