Please use this identifier to cite or link to this item:
Title: Cognitive impairment in Brazilian patients with Behcet's disease occurs independently of neurologic manifestation
Authors: Dutra, Livia Almeida [UNIFESP]
Silva de Souza, Alexandre Wagner [UNIFESP]
Alessi, Helena [UNIFESP]
Sobreira Guedes, Bruno de Vasconcelos
Braga-Neto, Pedro [UNIFESP]
Pedroso, Jose Luiz [UNIFESP]
Goncalves, Celio Roberto
Rocha, Antonio Jose da
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Barsottini, Orlando Graziani Povoas [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fac Ciencias Med Santa Casa São Paulo
Universidade de São Paulo (USP)
Keywords: Behcet's syndrome
Neuro-Behcet's disease
Cognitive dysfunction
Educational level
Issue Date: 15-Apr-2013
Publisher: Elsevier B.V.
Citation: Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 327, n. 1-2, p. 1-5, 2013.
Abstract: Neuro-Behcet's disease (NBD) presents cognitive and behavioral symptoms possibly explained by secondary dysfunction of frontal and temporal cortices due to subcortical damage, as NBD commonly involves the brainstem and basal ganglia. Nonetheless, there are reports of cognitive impairment in patients without neurological manifestations.Objective: To evaluate cognitive function in Behcet's disease (BD) patients with and without neurological manifestations and to analyze clinical variables associated with cognitive deficits.Methods: This is a cross-sectional study that compared healthy controls, BD patients without neurological manifestations and NBD patients. Each group comprised 24 participants. All participants underwent neuropsychological evaluation, Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory (BDI) application and brain MRI. Cumulative prednisone dose, years of education, and presence of white-matter lesions in brain MRI were recorded.Results: 41.6% of BD and 41.6% of NBD patients showed impaired language and executive function, whereas visual memory was impaired only in NBD patients. Multiple logistic regression revealed that anxiety (OR 1.09 95% CI 1.03-1.16, p = 0.003) and lower educational level (OR 0.62 95% CI 0.48-0.80, p<0.0001) were independently associated with cognitive impairment.Conclusion: Cognitive impairment occurs frequently in patients with BD independently of neurological manifestation. Low educational level and anxiety are risk factors for cognitive impairment in BD. (c) 2013 Elsevier B.V. All rights reserved.
ISSN: 0022-510X
Other Identifiers:
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.