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Title: Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
Authors: Souza, Lucas R. de
Melo, Pollyana Maria Saud [UNIFESP]
Paschoalin, Thaysa [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Kondo, Marcia Yuri [UNIFESP]
Hirata, Izaura Yoshico [UNIFESP]
Blaber, Michael
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Takatsuka, Joyce
Juliano, Maria Aparecida [UNIFESP]
Juliano, Luiz [UNIFESP]
Gomes, Roseli A.
Puzer, Luciano
Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Florida State Univ
Univ Mogi das Cruzes
Univ Fed Triangulo Mineiro
Keywords: Plasminogen
Issue Date: 12-Apr-2013
Publisher: Elsevier B.V.
Citation: Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.
Abstract: Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.
ISSN: 0006-291X
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