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Title: Predictive Factors of Overall Well-Being Using the EORTC QLQ-C15-PAL Extracted from the EORTC QLQ-C30
Authors: Lam, Kinsey
Zeng, Liang
Zhang, Liying
Tseng, Ling-Ming
Hou, Ming-Feng
Fairchild, Alysa
Vassiliou, Vassilios
Jesus-Garcia, Reynaldo [UNIFESP]
El-Din, Mohamed A. Alm
Kumar, Aswin
Forges, Fabien
Chie, Wei-Chu
Sahgal, Arjun
Poon, Michael
Chow, Edward
Univ Toronto
Natl Yang Ming Univ
Kaohsiung Med Univ Hosp
Cross Canc Inst
Bank Cyprus Oncol Ctr
Universidade Federal de São Paulo (UNIFESP)
Tanta Univ Hosp
Reg Canc Ctr
St Etienne Univ Hosp
Natl Taiwan Univ
Issue Date: 1-Apr-2013
Publisher: Mary Ann Liebert Inc
Citation: Journal of Palliative Medicine. New Rochelle: Mary Ann Liebert Inc, v. 16, n. 4, p. 402-408, 2013.
Abstract: Objective: the European Organization of Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core 15 Palliative (EORTC QLQ-C15-PAL) was developed to assess quality of life (QOL) for the palliative cancer population to decrease patient burden. the purpose of this study was to compare predictive factors for well-being in the QLQ-C15-PAL extracted from the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30) with the QLQ-C30 itself.Methods and Materials: Patients with advanced cancer referred for treatment of bone metastases completed the QLQ-C30. Fifteen items from the QLQ-C15-PAL were extracted from the QLQ-C30. Univariate and multivariate analyses were used to determine predictive factors of the global QOL/health score in both tools. in the multivariate analyses, a p value of < 0.003 indicated statistical significance.Results: Overall, predictive factors were similar when analyzing data from both tools. Predictive factors for the QLQ-C30 were role functioning (p < 0.0001), fatigue (p < 0.0001), nausea/vomiting (p < 0.0001), and financial problems (p < 0.0001) and factors for the extracted QLQ-C15-PAL were physical functioning (p < 0.0001) and fatigue (p < 0.0001).Conclusions: Extraction of the QLQ-C15-PAL items from the QLQ-C30 resulted in similar predictive QOL domains for all patient subgroups analyzed individually. the QLQ-C15-PAL is reflective of the QLQ-C30 domains and is recommended for future studies involving patients in a palliative setting, as this shorter questionnaire reduces patient burden and may increase accrual and compliance, while maintaining a similar breadth of coverage and achieving the same predictive ability.
ISSN: 1096-6218
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