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Title: ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia
Authors: Ota, Vanessa K. [UNIFESP]
Gadelha, Ary [UNIFESP]
Assuncao, Idaiane B. [UNIFESP]
Santoro, Marcos L. [UNIFESP]
Christofolini, Denise M.
Bellucco, Fernanda T. [UNIFESP]
Santos-Filho, Airton F. [UNIFESP]
Ottoni, Gustavo L.
Lara, Diogo R.
Mari, Jair J. [UNIFESP]
Melaragno, Maria I. [UNIFESP]
Smith, Marilia A. C. [UNIFESP]
Bressan, Rodrigo A. [UNIFESP]
Belangero, Sintia I. [UNIFESP]
Jackowski, Andrea P. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Rio Grande Sul PUCRS
Keywords: Schizophrenia
Cortical volumes
Issue Date: 1-Apr-2013
Publisher: Elsevier B.V.
Citation: Schizophrenia Research. Amsterdam: Elsevier B.V., v. 145, n. 1-3, p. 33-35, 2013.
Abstract: ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved.
ISSN: 0920-9964
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