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dc.contributor.authorMurakami, Cynthia
dc.contributor.authorLago, Joao H. G. [UNIFESP]
dc.contributor.authorPerazzo, Fabio F. [UNIFESP]
dc.contributor.authorFerreira, Karen S. [UNIFESP]
dc.contributor.authorLima, Marcos E. L.
dc.contributor.authorMoreno, Paulo R. H.
dc.contributor.authorYoung, Maria C. M.
dc.identifier.citationChemistry & Biodiversity. Weinheim: Wiley-v C H Verlag Gmbh, v. 10, n. 4, p. 621-627, 2013.
dc.description.abstractThe chemical compositions and antimicrobial activities of essential oils from the leaves, stems, capitula, and cypselas of Chromolaena laevigata were evaluated at two different phenological stages, flowering and fruiting. Thirty-eight compounds were identified in the crude oils by GC/MS. the sesquiterpene laevigatin was the major constituent of the leaf, capitulum, and cypsela oils, while the sesquiterpene spathulenol was the main component in the stem oils. the antimicrobial activities of the oils were evaluated against Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Stem oil obtained from Chromolaena laevigata during the fruiting stage generally showed the highest activity with minimum inhibitory concentration (MIC) values of 62.5g/ml against Candida albicans and S. aureus, and 500g/ml against P. aeruginosa and E. coli. Pure laevigatin exhibited MIC values of 500 and 125g/ml against C. albicans and S. aureus, respectively, indicating that this constituent could be responsible, at least in part, for the antimicrobial activities detected in the crude oils. More studies concerning the biological activities of isolated derivatives are required to improve our knowledge of the antimicrobial potential of volatile compounds present in native plants.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.relation.ispartofChemistry & Biodiversity
dc.rightsAcesso restrito
dc.subjectChromolaena laevigataen
dc.subjectEssential oilsen
dc.subjectAntimicrobial activityen
dc.titleChemical Composition and Antimicrobial Activity of Essential Oils from Chromolaena laevigata during Flowering and Fruiting Stagesen
dc.contributor.institutionInst Bot
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationInst Bot, Secretaria Meio Ambiente, BR-04301902 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
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