Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/36103
Title: Monitoring for HHV-6 Infection After Renal Transplantation: Evaluation of Risk Factors for Sustained Viral Replication
Authors: Luiz, Claudia R. [UNIFESP]
Machado, Clarisse M.
Canto, Cynthia L. M.
Christ, Silvia C. C. [UNIFESP]
Pestana, Jose O. M. [UNIFESP]
Kotton, Camille N.
Camargo, Luis F. A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Massachusetts Gen Hosp
Keywords: Human herpesvirus 6 (HHV-6)
Renal transplantation
PCR
Active viral infection
Sustained viral replication
Issue Date: 27-Mar-2013
Publisher: Lippincott Williams & Wilkins
Citation: Transplantation. Philadelphia: Lippincott Williams & Wilkins, v. 95, n. 6, p. 842-846, 2013.
Abstract: Background. Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear.Methods. Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 replication between February 2007 and February 2008. Plasma samples for DNA detection were collected from the donor and the recipient before transplantation and from the recipient weekly for the first 2 months after transplantation and then every 2 weeks for 2 additional months. HHV-6 active infection was defined as detection of viral DNA in plasma, by polymerase chain reaction, in at least two consecutive samples over an interval of at least 1 week.Results. Active viral infection was detected in 25% of the recipients before transplantation and 27% (8 of 30) of the patients after transplantation. the mean time to onset of viral replication was 28.1 days after transplantation and 7 of 8 (87.5%) were asymptomatic. Risk factors associated with active HHV-6 infection were receiving an organ from a living donor (P=0.028), recipients with IgM antibodies detected before transplantation (P=0.005), and pretransplantation recipient HHV-6 viral load more than 10,000 copies/mL plasma (P=0.034).Conclusions. Active HHV-6 infection occurs early after renal transplantation and is mostly asymptomatic. Donor or recipient infection may occur at the time of transplantation and are related to higher rates of posttransplantation infections.
URI: http://repositorio.unifesp.br/handle/11600/36103
ISSN: 0041-1337
Other Identifiers: http://dx.doi.org/10.1097/TP.0b013e3182807ab7
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.