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Title: European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil
Authors: Brum, Doralina Guimaraes
Luizon, Marcelo Rizzatti
Santos, Antonio Carlos
Lana-Peixoto, Marco Aurelio
Rocha, Cristiane Franklin
Brito, Maria Lucia
Lobato de Oliveira, Enedina Maria [UNIFESP]
Bichuetti, Denis Bernardi [UNIFESP]
Gabbai, Alberto Alain [UNIFESP]
Diniz, Denise Sisterolli
Kaimen-Maciel, Damacio Ramon
Comini-Frota, Elizabeth Regina
Vieira Wiezel, Claudia E.
Netto Muniz, Yara Costa
Silva Costa, Roberta Martins da
Mendes-Junior, Celso Teixeira
Donadi, Eduardo Antonio
Barreira, Amilton Antunes
Simoes, Aguinaldo Luiz
Universidade de São Paulo (USP)
Universidade Federal de Minas Gerais (UFMG)
Hosp Restauracao
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Universidade Estadual de Londrina (UEL)
Issue Date: 20-Mar-2013
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 8, n. 3, 5 p., 2013.
Abstract: Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirao Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirao Preto (NMO-RP).Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. in contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population.Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.
ISSN: 1932-6203
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