Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/3605
Title: Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection
Other Titles: Suscetibilidade dos Staphylococcus coagulase negativo meticilina-resistentes e suscetíveis isolados em infecções oculares
Authors: Oliveira, Adália Dias Dourado [UNIFESP]
Hofling-Lima, Ana Luisa [UNIFESP]
Belfort, Rubens Junior [UNIFESP]
Gayoso, Maria de Fátima
Francisco, Waldemar
Universidade Federal de São Paulo (UNIFESP)
Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
Keywords: Drug resistance
Eye infections, bacterial
Staphylococcus
Coagulase
Fluoroquinolones
Methicillin-resistance
Resistência microbiana a drogas
Infecções oculares bacterianas
Staphylococcus
Coagulase
Fluoroquinolonas
Resistência a meticilina
Issue Date: 1-Mar-2007
Publisher: Conselho Brasileiro de Oftalmologia
Citation: Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 70, n. 2, p. 286-289, 2007.
Abstract: PURPOSE: To evaluate the fluoroquinolone susceptibilities of ocular isolate coagulase-negative staphylococci (CoNS), identified at the Microbiology Laboratory - UNIFESP. DESIGN: Experimental laboratory investigation. METHODS: The minimum inhibitory concentrations (MICs) of 21 strains of methicillin-resistant coagulase-negative staphylococci (MRCoNS) and 22 methicillin-sensitive coagulase-negative staphylococci (MSCoNS) to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were determined, using the E-test method standardized by the Clinical and Laboratory Standards Institute (CLSI/NCCLS). RESULTS: The MIC90s (µg/ml) for the second generation of tested fluoroquinolones were higher than the fourth generation, especially for the methicillin-resistant coagulase-negative staphylococci group. CONCLUSION: Our results indicate that methicillin-sensitive coagulase-negative staphylococci are more susceptible to quinolones than are methicillin-resistant coagulase-negative staphylococci and that fourth generation fluoroquinolones appear to be more potent, affecting even coagulase-negative staphylococcal strains resistant to second generation fluoroquinolones.
OBJETIVOS: Avaliar a suscetibilidade a fluorquinolonas dos Staphylococcus coagulase-negativo (SCoN) identificados no Laboratório de Microbiologia Ocular da UNIFESP. MÉTODOS: Foi determinada a concentração inibitória mínima de 21 cepas de SCoN meticilina-resistentes e 22 meticilina-sensíveis para ciprofloxacina, ofloxacina, gatifloxacina e moxifloxacina, utilizando o E-test estandartizado pelo CLSI/NCCLS. RESULTADOS: Os MIC90 (µg/ml) de 43 SCoN isolados para fluorquinolonas de segunda geração foram maiores do que os de quarta geração, principalmente para o grupo dos meticilina-resistentes. CONCLUSÃO: Nossos resultados indicam que Staphylococcus coagulase-negativo meticilina-sensíveis são mais suscetíveis às quinolonas do que os Staphylococcus coagulase-negativo meticilina-resistentes, fluorquinolonas de quarta geração parecem ser mais potentes, cobrindo inclusive cepas de Staphylococcus coagulase-negativo resistentes à segunda geração de fluorquinolonas.
URI: http://repositorio.unifesp.br/handle/11600/3605
ISSN: 0004-2749
Other Identifiers: http://dx.doi.org/10.1590/S0004-27492007000200018
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