Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/35974
Title: ANGIOTENSIN (5-8) MODULATES NOCICEPTION AT the RAT PERIAQUEDUCTAL GRAY VIA the NO-sGC PATHWAY and AN ENDOGENOUS OPIOID
Authors: Guethe, L. M.
Pelegrini-da-Silva, A.
Borelli, K. G.
Juliano, M. A. [UNIFESP]
Pelosi, G. G.
Pesquero, J. B. [UNIFESP]
Silva, C. L. M.
Correa, F. M. A.
Murad, F.
Prado, W. A.
Martins, A. R.
Universidade de São Paulo (USP)
Univ Fed Triangulo Mineiro
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
George Washington Univ
Universidade Estadual de Londrina (UEL)
Keywords: angiotensin (5-8)
antinociception
pain
periaqueductal gray matter
incision allodynia model
tail-flick test
Issue Date: 12-Feb-2013
Publisher: Elsevier B.V.
Citation: Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 231, p. 315-327, 2013.
Abstract: Angiotensins (Angs) modulate blood pressure, hydro-electrolyte composition, and antinociception. Although Ang (5-8) has generally been considered to be inactive, we show here that Ang (5-8) was the smallest Ang to elicit dose-dependent responses and receptor-mediated antinociception in the rat ventrolateral periaqueductal gray matter (vlPAG). Ang (5-8) antinociception seems to be selective, because it did not alter blood pressure or act on vascular or intestinal smooth muscle cells. the non-selective Ang-receptor (Ang-R) antagonist saralasin blocked Ang (5-8) antinociception, but selective antagonists of Ang-R types I, II, IV, and Mas did not, suggesting that Ang (5-8) may act via an unknown receptor. Endopeptidase EP 24.11 and amastatin-sensitive aminopeptidase from the vlPAG catalyzed the synthesis (from Ang II or Ang III) and inactivation of Ang (5-8), respectively. Selective inhibitors of neuronal-nitric oxide (NO) synthase, soluble guanylyl cyclase (sGC) and a nonselective opioid receptor (opioid-R) inhibitor blocked Ang (5-8)-induced antinociception. in conclusion, Ang (5-8) is a new member of the Ang family that selectively and strongly modulates antinociception via NO-sGC and endogenous opioid in the vlPAG. (c) 2012 IBRO. Published by Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/35974
ISSN: 0306-4522
Other Identifiers: http://dx.doi.org/10.1016/j.neuroscience.2012.11.048
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