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Title: Sleep disorders in Machado-Joseph disease: A dopamine transporter imaging study
Authors: Pedroso, Jose Luiz [UNIFESP]
Braga-Neto, Pedro [UNIFESP]
Felicio, Andre C. [UNIFESP]
Minett, Thais [UNIFESP]
Yamaguchi, Elton [UNIFESP]
Prado, Lucila Bizari Fernandes do [UNIFESP]
Carvalho, Luciane Bizari C. [UNIFESP]
Dutra, Livia Almeida [UNIFESP]
Hoexter, Marcelo Queiroz [UNIFESP]
Rocha, Antonio Jose da
Bressan, Rodrigo A. [UNIFESP]
Prado, Gilmar Fernandes do [UNIFESP]
Barsottini, Orlando Graziani Povoas [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Santa Casa de Misericordia São Paulo
Keywords: Spinocerebellar ataxia type 3
Machado-Joseph disease
Sleep disorders
Dopamine transporter
Issue Date: 15-Jan-2013
Publisher: Elsevier B.V.
Citation: Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 324, n. 1-2, p. 90-93, 2013.
Abstract: Objectives: Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado-Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities.Patients and methods: Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent clinical sleep evaluation and polysomnography. SPED' with [Tc-99m]-TRODAT-1, was performed in all subjects.Results: DAT densities were significantly reduced in MJD group when compared to controls. No significant correlation was found between DAT densities and RLS or RBD in MJD.Conclusion: Our study failed to demonstrate a clear correlation between sleep disorders and DAT densities in MJD patients, hence suggesting that extrastriatal and non-presynaptic dopamine pathways could be implicated in MJD-related sleep disorders. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0022-510X
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