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Title: Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome
Authors: Izar, Maria C. [UNIFESP]
Fonseca, Henrique A. [UNIFESP]
Pinheiro, Luiz F. [UNIFESP]
Monteiro, Carlos M. [UNIFESP]
Povoa, Rui M. [UNIFESP]
Monteiro, Andrea M.
Figueiredo-Neto, Antonio M.
Gidlund, Magnus A.
Fonseca, Francisco A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Acute coronary syndrome (ACS)
autoantibodies (Abs)
metabolic syndrome (MetS)
oxidized low-density lipoprotein (oxLDL)
Issue Date: 1-Jan-2013
Publisher: Sage Publications Ltd
Citation: Diabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 10, n. 1, p. 32-39, 2013.
Abstract: Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. the severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). in conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.
ISSN: 1479-1641
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