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Title: Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins
Authors: Tjaderhane, Leo
Nascimento, Fabio D.
Breschi, Lorenzo
Mazzoni, Annalisa
Tersariol, Ivarne L. S. [UNIFESP]
Geraldeli, Saulo
Tezvergil-Mutluay, Arzu
Carrilho, Marcela R.
Carvalho, Ricardo M.
Tay, Franklin R.
Pashley, David H.
Univ Oulu
Oulu Univ Hosp
Nord Inst Dent Mat NIOM
Univ Bandeirante São Paulo
Univ Trieste
Rizzoli Orthoped Inst
Univ Mogi das Cruzes
Universidade Federal de São Paulo (UNIFESP)
Univ Florida
Univ Turku
Turku Univ Hosp
Univ Western Ontario
Univ British Columbia
Med Coll Georgia
Keywords: Matrix metalloproteinase
Cysteine cathepsin
Composite resin
Issue Date: 1-Jan-2013
Publisher: Elsevier B.V.
Citation: Dental Materials. Oxford: Elsevier B.V., v. 29, n. 1, p. 116-135, 2013.
Abstract: Objectives. Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. the preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability.Methods. Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface.Results. the identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength.Significance. Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future. (c) 2012 Academy of Dental Materials. Published by Elsevier B.V. All rights reserved.
ISSN: 0109-5641
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