Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35720
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dc.contributor.authorVelloso, Elvira Deolinda Rodrigues Pereira
dc.contributor.authorChauffaille, Maria de Lourdes [UNIFESP]
dc.contributor.authorPelicario, L. M.
dc.contributor.authorTanizawa, Roberta Sandra da Silva
dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.authorGaiolla, R. D.
dc.contributor.authorLopes, L. F.
dc.date.accessioned2016-01-24T14:30:55Z
dc.date.available2016-01-24T14:30:55Z
dc.date.issued2013-01-01
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20122449
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35720
dc.description.abstractMyelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.en
dc.format.extent85-90
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectChildhood myelodysplastic syndromesen
dc.subjectJuvenile myelomonocytic leukemiaen
dc.subjectCytogeneticsen
dc.subjectKaryotypeen
dc.subjectDiagnosisen
dc.titleCytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging countryen
dc.typeArtigo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Canc Barretos
dc.contributor.institutionCtr Tratamento Fabiana Macedo de Morais
dc.description.affiliationUniv São Paulo, Fac Med, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Hematol, Lab Citogenet, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationHosp Canc Barretos, Barretos, SP, Brazil
dc.description.affiliationCtr Tratamento Fabiana Macedo de Morais, Grp Assistencia Crianca Canc, Grp Cooperat Brasileiro Sindrome Mielodisplas Ped, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, Brazil
dc.identifier.fileS0100-879X2013000100085.pdf
dc.identifier.scieloS0100-879X2013000100085
dc.identifier.doi10.1590/1414-431X20122449
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000316126700011
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