Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35709
Title: Glutamine/Glutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses
Authors: Goldman, Suzan M. [UNIFESP]
Nunes, Thiago F. [UNIFESP]
Melo, Homero J. F. [UNIFESP]
Dalavia, Claudio [UNIFESP]
Szejnfeld, Denis [UNIFESP]
Kater, Claudio [UNIFESP]
Andreoni, Cassio [UNIFESP]
Szejnfeld, Jacob [UNIFESP]
Ajzen, Sergio A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jan-2013
Publisher: Hindawi Publishing Corporation
Citation: Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2013.
Abstract: Purpose. To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). Materials and Methods. Institutional review board approval and informed consent were obtained. A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54 +/- 14.8 years). A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence. Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx. Lac/Cr and Glx/Cr were calculated. Glx/Cr was assessed in relation to lesion size. Results. Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P < 0.05), however, with a low positive predictive value (PPV). Glx levels were directly proportional to lesion size in carcinomas. A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy. Lac/Cr results showed no differences across lesions. A cutoff point of -6.5 for Lac/Cr was established for carcinoma diagnosis. Conclusion. Glx levels are directly proportional to lesion size in carcinomas. A cutoff point of -6.5 Lac/Cr differentiates carcinomas from noncarcinomas.
URI: http://repositorio.unifesp.br/handle/11600/35709
ISSN: 2314-6133
Other Identifiers: http://dx.doi.org/10.1155/2013/835385
Appears in Collections:Em verificação - Geral

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