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Title: Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease
Authors: Gregorio, Michele L.
Pinhel, Marcela A. S.
Sado, Caroline L. [UNIFESP]
Longo, Gabriela S.
Oliveira, Fabio N.
Amorim, Gisele S.
Nakazone, Marcelo A.
Florim, Greiciane M.
Mazeti, Camila M.
Martins, Denise P.
Tognola, Waldir A.
Brandao, Antonio C.
Pinheiro Junior, Sidney
Godoy, Moacir F. de
Souza, Doroteia R. S. [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Base
Sao Jose do Rio Preto Med Sch FAMERP
Issue Date: 1-Jan-2013
Publisher: Hindawi Publishing Corporation
Citation: Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2013.
Abstract: The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. the studied polymorphism was analyzed by PCR/RFLP. the Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. the APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). the APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.
ISSN: 2314-6133
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