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Title: Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet
Authors: Cunha, Claudio Alexandre [UNIFESP]
Lira, Fabio Santos de
Rosa Neto, José Cesar [UNIFESP]
Pimentel, Gustavo Duarte
Souza, Gabriel Inacio Honorato de [UNIFESP]
Silva, Camila Morais Goncalves da
Souza, Claudio Teodoro de
Ribeiro, Eliane Beraldi [UNIFESP]
Sawaya, Alexandra Christine Helena Frankland
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Rodrigues, Bruno
Carvalho, Patricia de Oliveira
Oyama, Lila Missae [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina
Universidade Estadual de Campinas (UNICAMP)
Sao Francisco Univ USF
Univ Sao Judas Tadeu
Issue Date: 1-Jan-2013
Publisher: Hindawi Publishing Corporation
Citation: Mediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
Abstract: The aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice. Animals were randomized into four groups: CW (chow diet and water); CG (chow diet and water + green tea extract); HW (high-fat diet and water); HG (high-fat diet and water + green tea extract). the mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg bodyweight/day of green tea extract (CG and HG, resp.). the treatments were performed for eight weeks. UPLC showed that in 10 mg/mL green tea extract, there were 15 mu g/mg epigallocatechin, 95 mu g/mg epigallocatechin gallate, 20.8 mu g/mg epicatechin gallate, and 4.9 mu g/mg gallocatechin gallate. Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain. Further, we observed that green tea supplementation reduced inflammatory cytokine TNF alpha levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling. Our results show that green tea increases the lipolytic pathway and reduces adipose tissue, and this may explain the attenuation of low-grade inflammation in obese mice.
ISSN: 0962-9351
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