Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35687
Title: Can high altitude influence cytokines and sleep?
Authors: Lemos, Valdir de Aquino [UNIFESP]
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
Lira, Fabio Santos de [UNIFESP]
Rodrigues, Bruno
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
CEPE
Univ Sao Judas Tadeu
Universidade de São Paulo (USP)
Issue Date: 1-Jan-2013
Publisher: Hindawi Publishing Corporation
Citation: Mediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
Abstract: The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O-2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation because of the exposure to high altitudes, and these changes have been described as one of the responsible factors for the many consequences at high altitudes. We conducted a review of the literature during the period from 1987 to 2012. This work explored the relationships among inflammation, hypoxia and sleep in the period of adaptation and examined a novel mechanism that might explain the harmful effects of altitude on sleep, involving increased Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) production from several tissues and cells, such as leukocytes and cells from skeletal muscle and brain.
URI: https://repositorio.unifesp.br/handle/11600/35687
ISSN: 0962-9351
Other Identifiers: https://dx.doi.org/10.1155/2013/279365
Appears in Collections:Resenha

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