Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/35605
Title: Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
Authors: D'Alcante, Carina Chaubet
Diniz, Juliana Belo
Fossaluza, Victor
Batistuzzo, Marcelo Camargo
Lopes, Antonio Carlos
Shavitt, Roseli Gedanke
Deckersbach, Thilo
Malloy-Diniz, Leandro
Miguel, Euripedes Constantino
Hoexter, Marcelo Queiroz [UNIFESP]
Universidade de São Paulo (USP)
Harvard Univ
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Cognitive-behavioral therapy
Neuropsychology
Obsessive-compulsive disorder
Serotonin reuptake inhibitors
Treatment-naive
Issue Date: 3-Dec-2012
Publisher: Elsevier B.V.
Citation: Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012.
Abstract: Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/35605
ISSN: 0278-5846
Other Identifiers: http://dx.doi.org/10.1016/j.pnpbp.2012.07.002
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