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dc.contributor.authorFroeder, Leila [UNIFESP]
dc.contributor.authorArasaki, Carlos Haruo [UNIFESP]
dc.contributor.authorMalheiros, Carlos Alberto
dc.contributor.authorBaxmann, Alessandra Calabria [UNIFESP]
dc.contributor.authorHeilberg, Ita Pfeferman [UNIFESP]
dc.identifier.citationClinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 7, n. 12, p. 2033-2040, 2012.
dc.description.abstractBackground and objectives Bariatric surgery (BS) may be associated with increased oxalate excretion and a higher risk of nephrolithiasis. This study aimed to investigate urinary abnormalities and responses to an acute oxalate load as an indirect assessment of the intestinal absorption of oxalate in this population.Design, setting, participants, & measurements Twenty-four hour urine specimens were collected from 61 patients a median of 98 months after BS (post-BS) as well as from 30 morbidly obese (MO) participants; dietary information was obtained through 24-hour food recalls. An oral oxalate load test (OLT), consisting of 2-hour urine samples after overnight fasting and 2, 4, and 6 hours after consuming 375 mg of oxalate (spinach juice), was performed on 21 MO and 22 post-BS patients 12 months after BS. Ten post-BS patients also underwent OLT before surgery (pre-BS).Results There was a higher percentage of low urinary volume (<1.5 L/d) in post-BS versus MO (P<0.001). Hypocitraturia and hyperoxaluria (P=0.13 and P=0.36, respectively) were more frequent in BS versus MO patients. the OLT showed intragroup (P<0.001 for all periods versus baseline) and intergroup differences (P<0.001 for post-BS versus MO; P=0.03for post-BS versus pre-BS). the total mean increment in oxaluria after 6 hours of load, expressed as area under the curve, was higher in both post-BS versus MO and in post-BS versus pre-BS participants (P<0.001 for both).Conclusions the mean oxaluric response to an oxalate load is markedly elevated in post-bariatric surgery patients, suggesting that increased intestinal absorption of dietary oxalate is a predisposing mechanism for enteric hyperoxaluria. Clin J Am Soc Nephrol 7: 2033-2040, 2012. doi: 10.2215/CJN.02560312en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherAmer Soc Nephrology
dc.relation.ispartofClinical Journal of the American Society of Nephrology
dc.rightsAcesso aberto
dc.titleResponse to Dietary Oxalate after Bariatric Surgeryen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa Med Sch
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationSanta Casa Med Sch, Div Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2008/022794
dc.description.sponsorshipIDCNPq: 475681/2007-0
dc.description.sourceWeb of Science
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