Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35532
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dc.contributor.authorBatista, M. L.
dc.contributor.authorNeves, R. X.
dc.contributor.authorPeres, S. B.
dc.contributor.authorYamashita, A. S.
dc.contributor.authorShida, C. S. [UNIFESP]
dc.contributor.authorFarmer, S. R.
dc.contributor.authorSeelaender, M.
dc.date.accessioned2016-01-24T14:28:03Z-
dc.date.available2016-01-24T14:28:03Z-
dc.date.issued2012-12-01
dc.identifierhttp://dx.doi.org/10.1530/JOE-12-0307
dc.identifier.citationJournal of Endocrinology. Bristol: Bioscientifica Ltd, v. 215, n. 3, p. 363-373, 2012.
dc.identifier.issn0022-0795
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35532-
dc.description.abstractCancer cachexia induces loss of fat mass that accounts for a large part of the dramatic weight loss observed both in humans and in animal models; however, the literature does not provide consistent information regarding the set point of weight loss and how the different visceral adipose tissue depots contribute to this symptom. To evaluate that, 8-week-old male Wistar rats were subcutaneously inoculated with 1 ml (2 x 10(7)) of tumour cells (Walker 256). Samples of different visceral white adipose tissue (WAT) depots were collected at days 0, 4, 7 and 14 and stored at -80 degrees C (seven to ten animals/each day per group). Mesenteric and retroperitoneal depot mass was decreased to the greatest extent on day 14 compared with day 0. Gene and protein expression of PPAR gamma(2) (PPARG) fell significantly following tumour implantation in all three adipose tissue depots while C/EBP alpha (CEBPA) and SREBP-1c (SREBF1) expression decreased over time only in epididymal and retroperitoneal depots. Decreased adipogenic gene expression and morphological disruption of visceral WAT are further supported by the dramatic reduction in mRNA and protein levels of perilipin. Classical markers of inflammation and macrophage infiltration (f4/80, CD68 and MIF-1 alpha) in WAT were significantly increased in the later stage of cachexia (although showing a incremental pattern along the course of cachexia) and presented a depot-specific regulation. These results indicate that impairment in the lipid-storing function of adipose tissue occurs at different times and that the mesenteric adipose tissue is more resistant to the 'fat-reducing effect' than the other visceral depots during cancer cachexia progression. Journal of Endocrinology (2012) 215, 363-373en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent363-373
dc.language.isoeng
dc.publisherBioscientifica Ltd
dc.relation.ispartofJournal of Endocrinology
dc.rightsAcesso aberto
dc.titleHeterogeneous time-dependent response of adipose tissue during the development of cancer cachexiaen
dc.typeArtigo
dc.contributor.institutionUniv Mogi Das Cruzes
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionBoston Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Mogi Das Cruzes, Ctr Integrated Biotechnol, Lab Adipose Tissue Biol, BR-08780911 São Paulo, Brazil
dc.description.affiliationUniv Estadual Maringa, Dept Physiol Sci, Maringa, Parana, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Canc Metab Res Grp, São Paulo, Brazil
dc.description.affiliationBoston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA
dc.description.affiliationUniversidade Federal de São Paulo, Inst Sci & Technol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Sci & Technol, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2007/52782-1
dc.description.sponsorshipIDFAPESP: 2010/51078-1
dc.identifier.doi10.1530/JOE-12-0307
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000310881600004
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