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Title: The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates
Authors: Leal, Mariana Ferreira [UNIFESP]
Antunes, Lusania Maria Greggi
Lamarao, Maria Fernanda Vita
Silva, Carla Elvira Araujo da
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Assumpcao, Paulo Pimentel
Andrade, Edilson Ferreira
Rezende, Alexandre Pingarilho
Imbeloni, Aline Amaral
Muniz, Jose Augusto Pereira Carneiro
Pinto, Giovanny Reboucas
Smith, Marilia de Arruda Cardoso [UNIFESP]
Burbano, Rommel Rodríguez [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Fed Univ Para
Minist Saude
Univ Fed Piaui
Keywords: Canova
Homeopathic medicine
Non-human primates
Cebus apella
Issue Date: 1-Dec-2012
Publisher: Elsevier B.V.
Citation: Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 50, n. 12, p. 4412-4420, 2012.
Abstract: Background: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates.Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40 days. Micronucleus and comet assays were performed for the evaluation of DNA damage.Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. the frequency of these alterations was significantly lower in the Canova group than in the group without this medicine.Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0278-6915
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