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Title: Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22
Authors: Zeng, Liang
Chow, Edward
Bedard, Gillian
Zhang, Liying
Fairchild, Alysa
Vassiliou, Vassilios
El-Din, Mohamed A. Alm
Jesus-Garcia, Reynaldo [UNIFESP]
Kumar, Aswin
Forges, Fabien
Tseng, Ling-Ming
Hou, Ming-Feng
Chie, Wei-Chu
Bottomley, Andrew
Univ Toronto
Cross Canc Inst
Bank Cyprus Oncol Ctr
Tanta Univ Hosp
Universidade Federal de São Paulo (UNIFESP)
Reg Canc Ctr
St Etienne Univ Hosp
Natl Yang Ming Univ
Kaohsiung Med Univ Hosp
Natl Taiwan Univ
EORTC Headquarters
Issue Date: 1-Nov-2012
Publisher: Elsevier B.V.
Citation: International Journal of Radiation Oncology Biology Physics. New York: Elsevier B.V., v. 84, n. 3, p. E337-E342, 2012.
Abstract: Purpose: Radiation therapy (RT) is an effective method of palliating painful bone metastases and can improve function and reduce analgesic requirements. in advanced cancer patients, quality of life (QOL) is the primary outcome of interest over traditional endpoints such as survival. the purpose of our study was to compare bone metastasis-specific QOL scores among patients who responded differently to palliative RT.Methods and Materials: Patients receiving RT for bone metastases across 6 countries were prospectively enrolled from March 2010-January 2011 in a trial validating the QLQ-BM22 and completed the QLQ-BM22 and the core measure (QLQ-C30) at baseline and after 1 month. Pain scores and analgesic intake were recorded, and response to RT was determined according to the latest published guidelines. the Kruskal-Wallis nonparametric and Wilcoxon rank sum tests compared changes in QOL among response groups. A Bonferroni-adjusted P<.003 indicated statistical significance.Results: of 79 patients who received palliative RT, 59 were assessable. Partial response, pain progression, and indeterminate response were observed in 22, 8, and 29 patients, respectively; there were no patients with a complete response. Patients across all groups had similar baseline QOL scores apart from physical functioning (patients who progressed had better initial functioning). One month after RT, patients who responded had significant improvements in 3 of 4 QLQ-BM22 domains (painful site, P<.0001; painful characteristic, P<.0001; and functional interference, P<.0001) and 3 QLQ-C30 domains (physical functioning, P=.0006; role functioning, P=.0026; and pain, P<.0001). Patients with progression in pain had significantly worse functional interference (P=.0007) and pain (P=.0019).Conclusions: Patients who report pain relief after palliative RT also have better QOL with respect to bone metastasis-specific issues. the QLQ-BM22 and QLQ-C30 are able to discriminate among patients with varying responses and are recommended for use in future bone metastasis clinical trials. (C) 2012 Elsevier Inc.
ISSN: 0360-3016
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