Please use this identifier to cite or link to this item:
https://repositorio.unifesp.br/handle/11600/35277
Title: | Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
Authors: | Lira, Fabio Santos de [UNIFESP] Rosa Neto, José Cesar [UNIFESP] Pimentel, Gustavo Duarte [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] Carnier, June [UNIFESP] Sanches, Priscila de Lima [UNIFESP] Piano, Aline de [UNIFESP] Souza, Claudio T. de Tock, Lian [UNIFESP] Tufik, Sergio [UNIFESP] Mello, Marco Tulio de [UNIFESP] Seelaender, Marilia Cerqueira Leite [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Oyama, Lila Missae [UNIFESP] Dâmaso, Ana Raimunda [UNIFESP] Dept Fisiol Dept Biociencias Dept Psicobiol Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Univ So Santa Catarina |
Keywords: | Obesity Cytokines Endotoxin Insulin resistance Interdisciplinary therapy |
Issue Date: | 18-Sep-2012 |
Publisher: | Biomed Central Ltd |
Citation: | Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012. |
Abstract: | Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways. |
URI: | https://repositorio.unifesp.br/handle/11600/35277 |
ISSN: | 1475-2891 |
Other Identifiers: | https://dx.doi.org/10.1186/1475-2891-11-74 |
Appears in Collections: | Artigo |
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