Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/35277
Title: Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents
Authors: Lira, Fabio Santos de [UNIFESP]
Rosa, Jose C. [UNIFESP]
Pimentel, Gustavo D. [UNIFESP]
Santos, Ronaldo V. [UNIFESP]
Carnier, June [UNIFESP]
Sanches, Priscila L. [UNIFESP]
Piano, Aline de [UNIFESP]
Souza, Claudio T. de
Tock, Lian [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Seelaender, Marilia [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Damaso, Ana Raimunda [UNIFESP]
Dept Fisiol
Dept Biociencias
Dept Psicobiol
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ So Santa Catarina
Keywords: Obesity
Cytokines
Endotoxin
Insulin resistance
Interdisciplinary therapy
Issue Date: 18-Sep-2012
Publisher: Biomed Central Ltd
Citation: Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012.
Abstract: Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.
URI: http://repositorio.unifesp.br/handle/11600/35277
ISSN: 1475-2891
Other Identifiers: http://dx.doi.org/10.1186/1475-2891-11-74
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