Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35262
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dc.contributor.authorSoares, Irene S.
dc.contributor.authorFrancoso, Katia S.
dc.contributor.authorJampaulo, Vander O. [UNIFESP]
dc.contributor.authorRodrigues, Mauricio M. [UNIFESP]
dc.date.accessioned2016-01-24T14:27:41Z-
dc.date.available2016-01-24T14:27:41Z-
dc.date.issued2012-09-01
dc.identifierhttp://dx.doi.org/10.1586/ERV.12.82
dc.identifier.citationExpert Review of Vaccines. London: Expert Reviews, v. 11, n. 9, p. 1039-1041, 2012.
dc.identifier.issn1476-0584
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35262-
dc.description.abstractEvaluation of: Rodriguez D, Gonzalez-Aseguinolaza G, Rodriguez JR et al. Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium. PLoS ONE 7(4), e34445 (2012). Recently, a vaccine against malaria was successfully tested in a human Phase III trial. the efficacy of this vaccine formulation, based on the Plasmodium falciparum circumsporozoite protein, was approximately 50% and correlated with the presence of antibodies specific to the infective stages of the malaria parasites. Different strategies are being pursued to improve vaccine efficacy levels. One such strategy is the induction of specific cytotoxic T cells that can destroy the intracellular hepatocyte stages of the malaria parasite. in this study, a novel vaccination protocol was developed to elicit strong immune responses mediated by CD8(+) cytotoxic cells specific to the circumsporozoite protein. As proof-of-concept, the authors used the rodent malaria Plasmodium yoelii parasite. the vaccination strategy consisted of a heterologous prime-boost vaccination regimen involving porcine parvovirus-like particles for priming and the modified vaccinia virus Ankara for the booster immunization, both of which expressed the immunodominant CD8 epitope of the P. yoelii circumsporozoite protein. Results from this experimental model were extremely meaningful. This vaccination strategy led to a significant T-cell immune response mediated by CD8(+) multifunctional T effector and effector-memory cells. However, most importantly for the malaria vaccine development was the fact that following a sporozoite challenge, immunized mice eliminated more than 97% of the malaria parasites during the hepatocyte stages. These results confirm and extend a vast body of knowledge showing that a heterologous prime-boost vaccination strategy can elicit strong CD8(+) T-cell-mediated protective immunity and may increase the efficacy of malaria vaccines.en
dc.format.extent1039-1041
dc.language.isoeng
dc.publisherExpert Reviews
dc.relation.ispartofExpert Review of Vaccines
dc.rightsAcesso restrito
dc.subjectCD8(+) T cellsen
dc.subjectmalaria vaccineen
dc.subjectprime-boost vaccinationen
dc.subjectvirus-like particleen
dc.titleCD8(+) T-cell-mediated immunity against malaria: a novel heterologous prime-boost strategyen
dc.typeArtigo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Terapia Celular & Mol CTCMol, BR-04044010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Terapia Celular & Mol CTCMol, BR-04044010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 São Paulo, Brazil
dc.identifier.doi10.1586/ERV.12.82
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000312043400008
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