Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/35192
Title: BACTERIAL SENSING, CELL SIGNALING, and MODULATION of the IMMUNE RESPONSE DURING SEPSIS
Authors: Salomao, Reinaldo [UNIFESP]
Brunialti, Milena Karina Coló [UNIFESP]
Rapozo, Marjorie Marini [UNIFESP]
Baggio-Zappia, Giovana Lotici [UNIFESP]
Galanos, Chris
Freudenberg, Marina
Universidade Federal de São Paulo (UNIFESP)
Max Planck Inst Immunobiol
Keywords: LPS
tolerance
Toll-like receptor
monocytes
alternatively activated macrophages
T(H)1
Treg
T(H)17
Issue Date: 1-Sep-2012
Publisher: Lippincott Williams & Wilkins
Citation: Shock. Philadelphia: Lippincott Williams & Wilkins, v. 38, n. 3, p. 227-242, 2012.
Abstract: Since the definition of systemic inflammatory response syndrome/sepsis was originally proposed, a large amount of new information has been generated showing a much more complex scenario of inflammatory and counterinflammatory responses during sepsis. Moreover, some fundamental mechanisms of sensing and destroying invading microorganisms have been uncovered, which include the discovery of TLR4 as the lipopolysaccharide (LPS) gene, implications of innate immune cells as drivers of the adaptive response to infection, and the modulation of multiple accessory molecules that stimulate or inhibit monocyte/macrophage and lymphocyte interactions. the complexity of the infection/injury-induced immune response could be better appreciated with the application of genomics and proteomics studies, and LPS was a useful tool in many of these studies. in this review, we discuss aspects of bacterial recognition and induced cellular activation during sepsis. Because of the relevance of endotoxin (LPS) research in the field, we focus on LPS and host interactions as a clue to understand microorganisms sensing and cell signaling, then we discuss how this response is modulated in septic patients.
URI: http://repositorio.unifesp.br/handle/11600/35192
ISSN: 1073-2322
Other Identifiers: http://dx.doi.org/10.1097/SHK.0b013e318262c4b0
Appears in Collections:Em verificação - Geral

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