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Title: Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection
Authors: Elias, Rosa Maria [UNIFESP]
Correa-Costa, Matheus
Barreto, Claudiene Rodrigues [UNIFESP]
Silva, Reinaldo Correia [UNIFESP]
Hayashida, Caroline Y.
Castoldi, Angela [UNIFESP]
Goncalves, Giselle Martins
Braga, Tarcio Teodoro
Barboza, Renato
Rios, Francisco Jose
Keller, Alexandre Castro [UNIFESP]
Cenedeze, Marcos Antonio [UNIFESP]
Hyane, Meire Ioshie
D'Imperio-Lima, Maria Regina
Figueiredo-Neto, Antonio Martins
Reis, Marlene Antonia
Farias Marinho, Claudio Romero
Pacheco-Silva, Alvaro [UNIFESP]
Câmara, Niels Olsen Saraiva [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Fed Triangulo Mineiro
Inst Israelita Ensino & Pesquisa Albert Einstein
Issue Date: 31-Aug-2012
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 7, n. 8, 11 p., 2012.
Abstract: Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stress products, a characteristic of Plasmodium infection, as well as proinflammatory response induced by the parasite are involved in its pathophysiology. Therefore, we aimed to investigate the development of malaria-associated AKI during infection by P. berghei ANKA, with special attention to the role played by the inflammatory response and the involvement of oxidative stress. for that, we took advantage of an experimental model of severe malaria that showed significant changes in the renal pathophysiology to investigate the role of malaria infection in the renal microvascular permeability and tissue injury. Therefore, BALB/c mice were infected with P. berghei ANKA. To assess renal function, creatinine, blood urea nitrogen, and ratio of proteinuria and creatininuria were evaluated. the products of oxidative stress, as well as cytokine profile were quantified in plasma and renal tissue. the change of renal microvascular permeability, tissue hypoxia and cellular apoptosis were also evaluated. Parasite infection resulted in renal dysfunction. Furthermore, we observed increased expression of adhesion molecule, proinflammatory cytokines and products of oxidative stress, associated with a decrease mRNA expression of HO-1 in kidney tissue of infected mice. the measurement of lipoprotein oxidizability also showed a significant increase in plasma of infected animals. Together, our findings support the idea that products of oxidative stress, as well as the immune response against the parasite are crucial to changes in kidney architecture and microvascular endothelial permeability of BALB/c mice infected with P. berghei ANKA.
ISSN: 1932-6203
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