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Title: Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?
Authors: Moraes-Vieira, P. M. M.
Bassi, E. J.
Araujo, R. C. [UNIFESP]
Camara, N. O. S.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Foxp3
Issue Date: 1-Aug-2012
Publisher: Wiley-Blackwell
Citation: Obesity Reviews. Hoboken: Wiley-Blackwell, v. 13, n. 8, p. 733-743, 2012.
Abstract: Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. the modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.
ISSN: 1467-7881
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Appears in Collections:Em verificação - Geral

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