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Title: Cytogenetic biomonitoring in children submitting to a complete set of radiographs for orthodontic planning
Authors: Lorenzoni, Diego Coelho
Fracalossi, Ana Carolina Cuzzuol [UNIFESP]
Carlin, Viviane [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Sant' Anna, Eduardo Franzotti
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Micronucleus test
Buccal mucosa cells
Dental radiography
Issue Date: 1-Jul-2012
Publisher: E H Angle Education Research Foundation, Inc
Citation: Angle Orthodontist. Newton N: E H Angle Education Research Foundation, Inc, v. 82, n. 4, p. 585-590, 2012.
Abstract: Objectives: To evaluate the DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from children undergoing orthodontic radiographs.Materials and Methods: A total of 25 healthy children undergoing orthodontic therapy partook in a complete set of orthodontic radiographs (lateral cephalographic, posteroanterior cephalographic, panoramic, full periapical exam, and bitewing). the micronucleus test in the buccal exfoliated cells was applied. the paired-samples t-test and the Wilcoxon test were used to compare the frequencies of alterations before and after X-ray exposure.Results: We found no statistically significant differences (P > .05) between micronucleated buccal mucosa cells before and after exposure to radiation. However, radiation did cause other nuclear alterations closely related to cytotoxicity (P = .007).Conclusion: According to the micronucleus test, the complete set of radiographs requested in the orthodontic planning may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. (Angle Orthod. 2012;82:585-590.)
ISSN: 0003-3219
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