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dc.contributor.authorChiavegatto, Silvana
dc.contributor.authorSauce, Bruno
dc.contributor.authorAmbar, Guilherme
dc.contributor.authorCheverud, James M.
dc.contributor.authorPeripato, Andrea Cristina [UNIFESP]
dc.identifier.citationBrain and Behavior. Hoboken: John Wiley & Sons Inc, v. 2, n. 4, p. 365-376, 2012.
dc.description.abstractMaternal care is essential in mammals, and variations in the environment provided by mothers may directly influence the viability of newborns and emotional behavior later in life. A previous study investigated genetic variations associated with maternal care in an intercross of LG/J and SM/J inbred mouse strains and identified two single-locus QTLs (quantitative trait loci). Here, we selected three candidate genes located within these QTLs intervals; Oxt on chromosome 2, and FosB and Peg3 on chromosome 7 and tested their association with maternal care. LG/J females showed impaired postpartum nest building and pup retrieval, a one-day delay in milk ejection, reduced exploratory activity, and higher anxiety-like behavior when compared to SM/J females. the nucleotide sequences of Oxt and FosB were similar between strains, as were their hypothalamic expression levels. Conversely, Peg3 nucleotide sequences showed four nonsynonymous replacement substitutions on LG/J dams, T11062G, G13744A, A13808G, and G13813A, and a 30 base pair (10 aa) in tandem repeat in the coding region with three copies in SM/J and five copies in LG/J. Maternal care impaired LG/J mothers express 37% lower Peg3 mRNA levels in the hypothalamus on the second postpartum day. We also found an association of the Peg3 repeat-variant and poor maternal care in F-2 heterozygote females derived from a LG/J x SM/J intercross. These results may suggest that the maternally imprinted Peg3 gene is responsible for the single-locus QTL on chromosome 7 that has been shown to influence maternal care in these strains. Furthermore, these data provide additional support for an epigenetic regulation of maternal behavior.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.relation.ispartofBrain and Behavior
dc.rightsAcesso aberto
dc.subjectgene expressionen
dc.subjectgene variationen
dc.subjectmaternal behavioren
dc.titleHypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strainsen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNatl Inst Dev Psychiat Childhood & Adolescence IN
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionWashington Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept & Inst Psychiat, São Paulo, Brazil
dc.description.affiliationNatl Inst Dev Psychiat Childhood & Adolescence IN, São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Genet & Evolut, Biol Sci & Hlth Ctr, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationWashington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.sponsorshipIDFAPESP: 09/01333-8
dc.description.sponsorshipIDFAPESP: 04/14583-9
dc.description.sponsorshipIDFAPESP: 05/56353-2
dc.description.sourceWeb of Science
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