Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/34995
Title: Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease
Authors: Payão, Spencer Luiz Marques [UNIFESP]
Gonçalves, Gisela Moraes
Lábio, Roger Willian de
Horiguchi, Lie
Mizumoto, Igor
Rasmussen, Lucas Trevizani [UNIFESP]
Pinhel, Marcela Augusta de Souza
Souza, Dorotéia Rossi Silva
Bechara, Marcelo Dib
Chen, Elizabeth Suchi [UNIFESP]
Mazzotti, Diego Robles [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Smith, Marilia de Arruda Cardoso [UNIFESP]
USC
Universidade Federal de São Paulo (UNIFESP)
Fac Med Marilia FAMEMA
Fac Med Sao Jose do Rio Preto
Univ Marilia UNIMAR
Keywords: Alzheimer's disease
Interleukin-1 beta
Polymorphisms
Haplotypes
Receptor antagonist
Issue Date: 15-Jun-2012
Publisher: Elsevier B.V.
Citation: Journal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 247, n. 1-2, p. 59-62, 2012.
Abstract: Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/34995
ISSN: 0165-5728
Other Identifiers: http://dx.doi.org/10.1016/j.jneuroim.2012.03.012
Appears in Collections:Artigo

Files in This Item:
File Description SizeFormat 
WOS000304792900008.pdf192.63 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.